Enzyme alterations following nitrogen dioxide exposure

Journal Article · Mon May 01 04:00:00 EDT 1967 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1967.10664820· OSTI ID:6185309

Buckley, R D; Balchum, O J

Oxygen consumption (QO/sub 2/) and aldolase and lactic dehydrogenase (LDH) determinations were performed on guinea pig lung, liver, kidney, and spleen tissue homogenates following continuous exposure to 10 ppm nitrogen dioxide (NO/sub 2/) for varying periods of time. Inhalation of NO/sub 2/ resulted in increased QO/sub 2/ values not only in the lung but also in kidney tissue for each exposure period. The QO/sub 2/ in the liver and spleen homogenates were significantly elevated following 32 days' exposure but did not show a consistent increase after other exposure periods. Aldolase activity was significantly elevated in lung following 12 days' exposure and in lung and liver following 32 days' exposure to NO/sub 2/. Significant decreases in aldolase activity were noted in lung, kidney, and spleen after 26 days' exposure. The LDH values were increased in lungs, liver, and kidneys as a result of inhalation of NO/sub 2/. The possibility of the presence of circulating substances resulting from the interaction of NO/sub 2/ and lung or blood tissue or from a general physiological stress reaction or both were suggested as possible explanations for enzyme and QO/sub 2/ alterations observed in kidneys, liver, and spleen. The possible effects of respiratory infection of the metabolism of lung tissue was also discussed.

• Research Organization: Univ. of Southern California, Los Angeles
• OSTI ID: 6185309
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 14; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDE-LYASES
ALDOLASE
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBON-CARBON LYASES
CHALCOGENIDES
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
GUINEA PIGS
INHALATION
INTAKE
KIDNEYS
LIVER
LUNGS
LYASES
MAMMALS
METABOLISM
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NONMETALS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
SPLEEN
VERTEBRATES