Distribution, retention, and elimination of pyrene in rats after inhalation

Journal Article · Thu Nov 01 04:00:00 EST 1979 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397909529822· OSTI ID:5518316

Mitchell, C E; Tu, K W

Pyrene was measured in tissues of Fischer 2344 rats at various times after inhalation of pyrene aerosols (500 ..mu..g/l; mass median diameter, 0.3 to 0.8 ..mu..m) for 1 h. Significant quantities of pyrene were found in nasal turbinates, trachea, lungs, kidney, and liver immediately after exposure. Clearance from the respiratory tract was rapid; concentrations in the trachea and lungs 48 h after exposure were 20 and 5% of the concentrations present 1/2 h after exposure. Pyrene also cleared from liver and kidney at a relatively rapid rate; concentrations in these tissues 48 h after exposure were approximately 10% of those 1/2 h after exposure. Concentrations in the gastrointestinal tract 24 h after exposure were 4 times those found 1/2 h after exposure. Pyrene cleared from the gastrointestinal tract approximately 4 d after exposure. Thus, inhaled pyrene is rapidly cleared from the respiratory tract by mucociliary action from the trachea and bronchi and by translocation from the respiratory tract to the liver and kidney; it is eliminated primarily through the gastrointestinal tract.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• OSTI ID: 5518316
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 5:6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMALS
AROMATICS
BODY
CLEARANCE
COLLOIDS
CONDENSED AROMATICS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
EXCRETION
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
GLANDS
HYDROCARBONS
INFORMATION
INHALATION
INTAKE
INTESTINES
ISOLATED VALUES
KIDNEYS
LIVER
LUNG CLEARANCE
LUNGS
MAMMALS
METABOLISM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PARTICLE SIZE
POLLUTION
PYRENE
RATS
RENAL CLEARANCE
RESPIRATORY SYSTEM
RODENTS
SIZE
SOLS
STOMACH
TISSUE DISTRIBUTION
TRACHEA
VERTEBRATES