Species differences in the distribution of inhaled butadiene in tissues
1,3-butadiene is produced commercially for use in the manufacture of elastomers, polymers and other chemicals. Recent inhalation carcinogenicity studies of butadiene indicate that B6C3F/sub 1/ mice are more sensitive to the tumorigenic effects of inhaled butadiene than are Sprague Dawley rats. The purpose of this investigation was to determine if there were differences in distribution in tissues of inhaled butadiene between rats and mice. Male Sprague Dawley rats and B6C3F/sub 1/ mice were exposed nose-only for 3.4 hr to (mean +/- SE) 1220 +/- 71 ..mu..g /sup 14/C-butadiene/L air and 121 +/- 2 ..mu..g /sup 14/C-butadiene/L air, respectively. Radioactivity was distributed widely in tissues immediately following exposure of both rats and mice to /sup 14/C-butadiene. In both species, respiratory tract tissue (lung, trachea, nasal turbinates), gastrointestinal tract (small and large intestine), liver, kidneys, urinary bladder and pancreas contained high concentrations of radioactivity within 1 hr after the end of a exposure. In all cases, tissues of mice contained 15 to 100 times the concentration of /sup 14/C-butadience equivalents per ..mu..m mole of butadiene inhaled than did rats. For both rats and mice, elimination of /sup 14/C from tissues and blood was rapid, with 77% to 99% of the initial tissue burden being eliminated with half-times of 2 to 10 hr. Within 1 hr after the end of exposure, all rat tissues retained a substantial amount of /sup 14/C that was associated with volatile material that was probably butadiene and/or metabolites. A similar observation was noted in mouse liver, the only tissue of mice examined. The data indicate that there were no apparent differences between rats and mice in tissue depots for /sup 14/C derived from butadiene, but that, per ..mu..mole of butadiene inhaled, tissues of mice attained significantly greater concentrations of /sup 14/C than did rats.
- Research Organization:
- Lovelace Biomedical and Environmental Institute, Albuquerque, NM (USA)
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 5378388
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Vol. 48:10
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BUTADIENE
CARCINOGENESIS
TISSUE DISTRIBUTION
BIOLOGICAL HALF-LIFE
CARBON 14 COMPOUNDS
GENETIC VARIABILITY
INHALATION
MICE
RATS
TRACER TECHNIQUES
ANIMALS
BIOLOGICAL VARIABILITY
DIENES
DISTRIBUTION
HYDROCARBONS
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
PATHOGENESIS
POLYENES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques