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Physiological significance of benzo(. cap alpha. )pyrene adsorbed to carbon blacks: elution studies, AHH determinations

Journal Article · · Am. Ind. Hyg. Assoc. J.; (United States)
Desorption of benzo(..cap alpha..)pyrene from commercial carbon blacks by tissue fluids in vitro is compared to arylhydrocarbon hydroxylase induction in mice at three levels of carbon black exposure. Less than 0.005% of the adsorbed benzo(..cap alpha..)pyrene content determined by soxhlet extraction in toluene is eluted by human plasma, swine serum, swine lung homogenate and swine lung washings. Statistically significant differences in elution efficiency are observed for the various tissue fluids and carbon blacks. There is no detectable increase in AHH level in mouse lung or liver tissues even at the highest carbon black exposure and consumption rate of 1g/g bdywt/year.
Research Organization:
Texas Tech Univ., Lubbock
OSTI ID:
6453617
Journal Information:
Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 42:7; ISSN AIHAA
Country of Publication:
United States
Language:
English