Effects of polyhalogenated aromatic hydrocarbons on benzo (A) pyrene hydroxylase activity in the intestine and liver
Journal Article
·
· Life Sci.; (United States)
Aryl hydrocarbon hydroxylase (AHH) has been measured as benzo(a)pyrene hydroxylase in the intestine and liver of rats and mice treated with a single dose of different polyhalogenated aromatic hydrocarbons. Maximal stimulation of liver AHH activity is reached with a dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) half as great as that necessary for maximal stimulation of the intestine. The duration of the effect of TCDD on intestinal AHH differs from the constant increase that occurs in the liver. Although the magnitude of the stimulation by 1,1,1-trichloro-2,2-bis(p-chloropheny1) ethane (DDT) is less than that of TCDD, the qualitative changes in intestinal and liver AHH are similar. The changes in activity of intestinal and hepatic AHH were not directly correlated in the tissues of rats treated with several other polyhalogenated aromatic hydrocarbons. Liver and intestinal AHH activity were affected differently by fasting. These results suggest that AHH activity in the intestine and liver has different control mechanisms.
- Research Organization:
- State Univ. of New York, Brooklyn
- OSTI ID:
- 5367750
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 26:17; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CONDENSED AROMATICS
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HYDROCARBONS
HYDROXYLASE
INTESTINES
LIVER
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
VERTEBRATES
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CONDENSED AROMATICS
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HYDROCARBONS
HYDROXYLASE
INTESTINES
LIVER
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
VERTEBRATES