Studies on the anticarcinogenic action of BHA: regioselective inhibition of benzo(a)pyrene metabolism
Thesis/Dissertation
·
OSTI ID:5213211
Butylated hydroxyanisole (BHA; 2(3)-tert-butyl-4-hydroxyanisole) is a food preservative that exhibits anticarcinogenic activity. BHA added in vitro inhibited AHH activity of hepatic microsomes. The AHH activity of lung microsomes were inhibited to a lesser extent by BHA than that of hepatic microsomes. The AHH activities of liver and lung microsomes became less susceptible to the inhibition of BHA after pretreatment of the animals with 3-methylcholanthrene or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but pretreatment with phenobarbital did not produce such an effect. Species and sex variation was not demonstrated between rats and mice. In skin homogenates, AHH activities of control rats and mice were not inhibited by BHA. The only skin sample whose AHH was inhibited by BHA is that from TCDD-treated mice. Kinetic analysis of BHA inhibiton on hepatic microsomal AHH activities indicated a mixed mechanism. BHA alters BP metabolism by direct inhibition and by altering the composition of microsomal P-450-dependent monooxygenase enzymes after chronic treatment. These changes can alter BP metabolism regioselectively in the liver and lung, a target tissue where diol epoxide formation is specifically inhibited. This provides a possible mechanism for the anticarcinogenic action of BHA.
- OSTI ID:
- 5213211
- Country of Publication:
- United States
- Language:
- English
Similar Records
Enzyme induction in rat lung and liver by condensates and fractions from main-stream and side-stream cigarette smoke
Biphenyl metabolism by rat liver microsomes. Regioselective effects of inducers, inhibitors, and solvents
Lung aryl hydrocarbon hydroxylase: inhibition following cadmium chloride inhalation. [Rats]
Journal Article
·
Mon Nov 30 23:00:00 EST 1987
· Environ. Res.; (United States)
·
OSTI ID:5649469
Biphenyl metabolism by rat liver microsomes. Regioselective effects of inducers, inhibitors, and solvents
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· Drug Metab. Dispos.; (United States)
·
OSTI ID:5236504
Lung aryl hydrocarbon hydroxylase: inhibition following cadmium chloride inhalation. [Rats]
Journal Article
·
Wed Nov 30 23:00:00 EST 1983
· Environ. Res.; (United States)
·
OSTI ID:6748127
Related Subjects
3-METHYLCHOLANTHRENE
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANISOLE
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CELL CONSTITUENTS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DIOXIN
ETHERS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INHIBITION
KINETICS
LIVER
LUNGS
MAMMALS
METABOLIC ACTIVATION
METABOLISM
MICE
MICROSOMES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANISOLE
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CELL CONSTITUENTS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DIOXIN
ETHERS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INHIBITION
KINETICS
LIVER
LUNGS
MAMMALS
METABOLIC ACTIVATION
METABOLISM
MICE
MICROSOMES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES