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Dioxin in soil: bioavailability after ingestion by rats and guinea pigs

Journal Article · · Science (Washington, D.C.); (United States)

Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.

Research Organization:
National Inst. of Environmental Health Sciences, Research Triangle Park, NC
OSTI ID:
6742673
Journal Information:
Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 223:4640; ISSN SCIEA
Country of Publication:
United States
Language:
English