Bioavailability and cytochrome P-450 induction from 2,3,7,8-tetrachlorodibenzo-P-dioxin contaminated soils from Times Beach, Missouri, and Newark, New Jersey

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Drug Chem. Toxicol.; (United States)

DOI:https://doi.org/10.3109/01480548809018111· OSTI ID:5900322

Umbreit, T H; Hesse, E J; Gallo, M A

Bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from contaminated soils from Times Beach, Missouri and Newark, New Jersey, was examined using liver concentrations and toxicity in guinea pigs observed up to 60 days following a single oral administration, and induction of cytochrome P-450 in rats sacrificed 24 hours after a single oral dose as endpoints. Both soils are contaminated with several chlorinated dioxins and numerous other compounds. Times Beach soil resulted in greater TCDD concentration in liver and TCDD was considerably more bioavailable from Times Beach soil than from Newark soil. However, both soils induced cytochrome P-450 activity to approximately the same extent. Moreover, similar banding patterns of microsomal proteins were seen on polyacrylamide electrophoretic gels. The many other compounds present in the soils, particularly in Newark, may account for the similar protein bands and levels of cytochrome P-450 observed.

• Research Organization: Univ. of Medicine and Dentistry of New Jersey, Piscataway (USA)
• OSTI ID: 5900322
• Journal Information: Drug Chem. Toxicol.; (United States), Journal Name: Drug Chem. Toxicol.; (United States) Vol. 11:4; ISSN DCTOD
• Country of Publication: United States
• Language: English

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510200 -- Environment
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54 ENVIRONMENTAL SCIENCES
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL AVAILABILITY
BODY
CELL CONSTITUENTS
CONTAMINATION
DIGESTIVE SYSTEM
DIOXIN
ELECTROPHORESIS
ENZYME ACTIVITY
ENZYME INDUCTION
ENZYMES
FEDERAL REGION II
FEDERAL REGION VII
GENE REGULATION
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GUINEA PIGS
HETEROCYCLIC COMPOUNDS
LIVER
MAMMALS
MICROSOMES
MISSOURI
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NEW JERSEY
NORTH AMERICA
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
RATS
RODENTS
SOILS
TOXICITY
USA
VERTEBRATES