Effect of 3-methylcholanthrene-induced increases in ascorbic acid levels on tissue. beta. -glucuronidase activity in rats
Journal Article
·
· J. Environ. Sci. Health, Part A; (United States)
The interrelationship between tissue ascorbic acid levels and tissue ..beta..-glucuronidase activity was examined in rats injected with 3-methylcholanthrene, an agent which induces ascorbic acid synthesis in rats. Six Fisher 344 rats were dosed intraperitoneally (IP) with 30 mg/kg of 3-methylcholanthrene. Ascorbic acid levels and ..beta..-glucuronidase (..beta..-G) activity were determined for lung, liver and kidney tissues. In a follow-up study, rats were dosed for three consecutive days with 3-methylcholanthrene. Controls in both groups were dosed IP with Emulphor (EL-620). Animals were sacrificed one week after the final dosage and lung, liver and kidney tissues were examined.
- Research Organization:
- Univ. of Massachusetts, Amherst (USA)
- OSTI ID:
- 7090454
- Journal Information:
- J. Environ. Sci. Health, Part A; (United States), Journal Name: J. Environ. Sci. Health, Part A; (United States) Vol. A23:1; ISSN JESED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
3-METHYLCHOLANTHRENE
550200 -- Biochemistry
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
ASCORBIC ACID
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
ENZYMES
EXTRAPOLATION
GLANDS
GLUCURONIDASE
GLYCOSYL HYDROLASES
HYDROCARBONS
HYDROLASES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
KINETICS
LIVER
LUNGS
MAMMALS
NUMERICAL SOLUTION
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
VITAMINS
550200 -- Biochemistry
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
ASCORBIC ACID
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
ENZYMES
EXTRAPOLATION
GLANDS
GLUCURONIDASE
GLYCOSYL HYDROLASES
HYDROCARBONS
HYDROLASES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
KINETICS
LIVER
LUNGS
MAMMALS
NUMERICAL SOLUTION
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
VITAMINS