Comparison of the suppressor cells found in the spleens of /sup 89/Sr-treated mice and in normal murine bone marrow

Journal Article · Sun Mar 01 04:00:00 EST 1981 · J. Immunol.; (United States)

OSTI ID:5571569

Levy, E M; Corvese, J S; Bennett, M

Normal murine bone marrow cells and spleen cells of mice treated with /sup 89/Sr both have suppressive activity. These nonspecific suppressor cells inhibit the ability of normal spleen cells to undergo antibody responses in vitro. After being precultured for 24 hr, these cells will also suppress antibody responses in vivo and the responses of normal spleen cells to T and B cell mitogens in vitro. These cells have previously been shown not to be mature T or B lymphocytes or macrophages. Velocity sedimentation and cell-size analysis indicated that both suppressor cells are large (approx. =206 ..mu../sup 3/). Mitomycin C treatment eliminated the ability of both suppressor cells to inhibit an in vitro antibody response. In contrast, this treatment did not reduce the ability of the cells to inhibit an in vitro antibody response. In contrast, this treatment did not reduce the ability of the cells to suppress a mitogenic response. Irradiation (1000 R) was also ineffective in eliminating the ability of either cell to suppress a mitogenic response. We conclude that the 2 suppressor cells are closely related if not identical, and we speculate that these cells may function in vivo to suppress immune reactivity in areas of intense hematopoiesis.

• Research Organization: Boston Univ. School of Medicine, MA
• OSTI ID: 5571569
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 126:3; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560122* -- Radiation Effects on Cells-- Internal Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BONE MARROW CELLS
CELL CULTURES
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
IMMUNOSUPPRESSION
IMMUNOSUPPRESSIVE DRUGS
IN VITRO
IN VIVO
INFORMATION
INHIBITION
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IRRADIATION
ISOTOPES
LETHAL IRRADIATION
MAMMALS
MICE
MITOGENS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN CELLS
STRONTIUM 89
STRONTIUM ISOTOPES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES