Action of T-activin on activity of human natural killer cells in vitro

Journal Article · Mon Sep 01 04:00:00 EDT 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00834421· OSTI ID:5563541

Cheknev, S B; Saidov, M Z; Koval'chuk, L V; Pavlyuk, A S; Arion, V Ya

This paper describes a study of the action of T-activin on activity of human natural killer cells (NKC) in vitro. The K-562 chronic human myeloid leukemia cells, cultured in vitro, used as targets were labeled with /sup 3/H-uridine. The experimental results indicate that T-activin can depress NKC activity but under certain conditions, it can also stimulate NKC. T-activin possesses immunoregulatory properties relative to NKC activity in vitro.

• Research Organization: N. I. Pirogov Second Moscow Medical Institute, USSR
• OSTI ID: 5563541
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:4; ISSN BEXBA
• Country of Publication: United States
• Language: English

Related Subjects

550301* -- Cytology-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL KILLING
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
FUNCTIONS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
IMMUNOSUPPRESSIVE DRUGS
INHIBITION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
LEUKEMIA
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MYELOID LEUKEMIA
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RIBOSIDES
SCINTILLATION COUNTING
SOMATIC CELLS
THYMUS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
URACILS
URIDINE
VERTEBRATES