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Effect of x-irradiation on immunocompetency of T-lymphocytes

Journal Article · · Cancer Clin. Trials; (United States)
OSTI ID:5546847
; ; ; ;
Effect of x-irradiation on various aspects of cell-mediated immune reactions is studied. The irradiated splenic lymphocytes could transform to blast cells upon stimulation with PHA, but could not divide into small lymphocytes. It was concluded that irradiation at doses higher than 500 rads inhibits the differentiation of lymphocytes to effector cells upon stimulation with antigens. The irradiated immune lymphocytes were able to kill target tumor cells when the cytotoxicity was tested immediately after irradiation with doses as high as 500 rads. The cytotoxicity of immune lymphocytes diminished, however, 7--10 hours after irradiation. The splenic lymphocytes irradiated with doses as high as 200 rads could stimulate allogeneic lymphocytes 2 days after the irradiation. It thus appeared that irradiation cannot immediately abolish the antigenicity of lymphocytes to stimulate allogeneic lymphocytes. The combined effect of irradiation and T-cell-mediated immune reaction to reduce clonogenecity of target tumor cells in vitro is simple additive.
Research Organization:
Radiobiology Laboratories, Department of Therapeutic Radiology, University of Minnesota Medical School, Minneapolis
OSTI ID:
5546847
Journal Information:
Cancer Clin. Trials; (United States), Journal Name: Cancer Clin. Trials; (United States) Vol. 4:3; ISSN CCTRD
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMAL CELLS
ANTIBODIES
AUTORADIOGRAPHY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOHYDRATES
CELL DIFFERENTIATION
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
HEMAGGLUTININS
IMMUNE REACTIONS
IMMUNOLOGY
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MITOGENS
MUCOPROTEINS
ORGANIC COMPOUNDS
ORGANS
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SACCHARIDES
SOMATIC CELLS
SPLEEN
TUMOR CELLS
X RADIATION