Radiation effects on the formation of effector cells and on the cytotoxicity of the effector cells

Conference · Thu Jan 01 04:00:00 EST 1976

OSTI ID:4066683

Song, C W; Levitt, S H

The effect of radiation on the transformation of lymphocytes to antigen- specific immune lymphocytes and also on the cytotoxicity of the immune lymphocytes against allogeneic tumor cells was studied. Irradiation of peripheral lymphocytes of rats with 1000 rads of x rays did not significantly impair the phytohemagglutinin-induced blastogenesis and DNA synthesis, but it inhibited the subsequent division of the blast cells. The cytolysis of tumor cells in vitro by splenic immune lymphocytes was quantitated with release of $sup 125$I-labeled iododeoxyuridine ($sup 125$I--IUdR) from the tumor cells labeled with the isotopes. The immune lymphocytes were rather radioresistant with regard to their cytotoxicity against the tumor cells. It was concluded that irradiation- induced immunosuppression might be due, not to a destruction of cytotoxic effector cells, but mainly to the suppression of formation of effector cells. (auth)

• Research Organization: Univ. of Minnesota, Minneapolis; Battelle Pacific Northwest Labs., Richland, Wash. (USA); USAEC Division of Biomedical and Environmental Research, Washington, D.C.
• NSA Number: NSA-33-023512
• OSTI ID: 4066683
• Report Number(s): CONF-740930--
• Country of Publication: United States
• Language: English

Related Subjects

*IMMUNE REACTIONS-- BIOLOGICAL RADIATION EFFECTS
*IMMUNOSUPPRESSION-- RADIOINDUCTION
*LYMPHOCYTES-- BIOLOGICAL RADIATION EFFECTS
*TUMOR CELLS-- IMMUNITY
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
IRRADIATION
MAN
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHYTOHEMAGGLUTININ
X RADIATION