Incidence of various types of thoracic malignancy induced in rats by intrapleural injection of 2 mg of various mineral dusts after inhalation of /sup 222/Ra

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/4.5.621· OSTI ID:5544997

Bignon, J; Jaurand, M C ^[1]; Monchaux, G ^[2]; Chameaud, J ^[3]; Lafuma, J; Masse, R ^[4]

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1. Lab. de Recherche sur les Affections Respiratoires et l'Environement, INSERM U 139, ERA CNRS No. 845 et Hopital Henri-Mondor, Creteil (France)
2. DDASS, Paris (France). Lab. d'Etude des Particles Inhalees
3. COGEMA, Razes (France). Lab. Experimental de Pathologie Respiratoire
4. CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire

After inhalation of /sup 222/Ra at equilibrium with radon daughters, male Sprague-Dawley rats were inoculated intrapleurally with 2 mg of unleached or acid-leached asbestos fibres or glass fibres or quartz. The additive co-carcinogenic effects of this type of insult were demonstrated by the increased incidence of malignant thoracic tumours. In rats given mineral materials, bronchopulmonary carcinomas and mixed carcinomas were observed, as well as typical mesotheliomas and combined pulmonary pleural tumours, whereas in control rats inhaling radon alone, only bronchopulmonary carcinomas occurred. No significant differences in tumour incidence were observed between the groups of animals given the different types of dusts, but statistically significant differences were noted in survival times, according to the histological type of tumour. The co-carcinogenic effects of an insult of the pleura by mineral dusts following inhalation of radon are discussed in relation to a possible tumour-promoting effect by these agents.

• OSTI ID: 5544997
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 4:5; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
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& Toxicology-- Animals
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASBESTOS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOGENESIS
CHALCOGENIDES
CHEST
DAUGHTER PRODUCTS
DISEASES
DUSTS
ELEMENTS
FLUIDS
GASES
GLASS
INHALATION
INTAKE
ISOTOPES
MAMMALS
MINERALS
NEOPLASMS
NONMETALS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
QUARTZ
RADIATION EFFECTS
RADIONUCLIDE KINETICS
RADIOSENSITIVITY EFFECTS
RADON
RARE GASES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SILICON COMPOUNDS
SILICON OXIDES
SURVIVAL TIME
SYNERGISM
VERTEBRATES