Incidence of various types of thoracic malignancy induced in rats by intrapleural injection of 2 mg of various mineral dusts after inhalation of /sup 222/Ra

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/4.5.621· OSTI ID:5347326

Bignon, J; Monchaux, G; Chameaud, J; Jaurand, M C; Lafuma, J; Masse, R

After inhalation of /sup 222/Ra at equilibrium with radon daughters, male Sprague-Dawley rats were inoculated intrapleurally with 2 mg of unleached or acid-leached asbestos fibres or glass fibres or quartz. The additive co-carcinogenic effects of this type of insult were demonstrated by the increased incidence of malignant thoracic tumours. In rats given mineral materials, bronchopulmonary carcinomas and mixed carcinomas were observed, as well as typical mesotheliomas and combined pulmonary pleural tumours, whereas in control rats inhaling radon alone, only bronchopulmonary carcinomas occurred. No significant differences in tumour incidence were observed between the groups of animals given the different types of dusts, but statistically significant differences were noted in survival times, according to the histological type of tumour. The co-carcinogenic effects of an insult of the pleura by mineral dusts following inhalation of radon are discussed in relation to a possible tumour-promoting effect by these agents.

• Research Organization: INSERM U 139, ERA CNRS No 845, Creteil, France
• OSTI ID: 5347326
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 4:5; ISSN CRNGD
• Country of Publication: United States
• Language: English

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560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANIMALS
ASBESTOS
BODY
CARCINOGENESIS
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DISEASES
DUSTS
EVEN-EVEN NUCLEI
FIBERS
GLASS
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
MAMMALS
MINERALS
NEOPLASMS
NUCLEI
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PROMOTERS
QUARTZ
RADIOISOTOPES
RADON 222
RADON ISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SILICON COMPOUNDS
SILICON OXIDES
SYNERGISM
TUMOR PROMOTERS
VERTEBRATES