Genetic component in rat mammary carcinogenesis
Journal Article
·
· Radiat. Res.; (United States)
Five genetically defined strains of female rats were exposed to whole-body radiation with a single dose of 50 rad of fission neutrons. After 1 year 56% of the Long-Evans and Sprague-Dawely strains showed at least one mammary tumor; 25-29% of the Buffalo and Fischer-344 strains and only 5% of the Wistar-Lewis strain and palpable mammary tumors. Only one tumor was found among 73 unirradiated controls during the 1-year observation period. Approximately two-thirds of 50 mammary analyzed pathologically were adenofibromas and fibroadenomas; one-third were adenocarcinomas. The Kaplan-Meier method of life table analysis was used to deal with the problem of intercurrent mortality. A genetic factor seems evident in rat mammary tumorigenesis following exposure to fission neutrons.
- Research Organization:
- Univ. of Tennessee Center for Health Sciences, Memphis
- OSTI ID:
- 5528731
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 89:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
CARCINOGENESIS
DISEASES
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FEMALES
FERMIONS
FISSION NEUTRONS
GENETIC EFFECTS
GENETICS
GLANDS
HADRONS
IRRADIATION
MAMMALS
MAMMARY GLANDS
NEOPLASMS
NEUTRONS
NUCLEONS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RATS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
CARCINOGENESIS
DISEASES
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FEMALES
FERMIONS
FISSION NEUTRONS
GENETIC EFFECTS
GENETICS
GLANDS
HADRONS
IRRADIATION
MAMMALS
MAMMARY GLANDS
NEOPLASMS
NEUTRONS
NUCLEONS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RATS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION