Synergism between neutron radiation and diethylstilbestrol in the production of mammary adenocarcinomas in the rat

Journal Article · Mon Mar 01 04:00:00 EST 1976 · Cancer Res.; (United States)

OSTI ID:7332007

Shellabarger, C J; Stone, J P; Holtzman, S

When young female A x C rats were given 9.6 rads of 0.43-MeV neutrons, 32 of 33 survived a 50-week follow-up period, 2 rats developed a total of 3 mammary adenocarcinomas, and 3 rats developed a total of 4 mammary fibroadenomas. For 25 rats implanted with a 20-mg pellet containing 5 mg diethylstilbestrol and 15 mg cholesterol, average survival was 284 days; 22 rats developed a total of 182 mammary adenocarcinomas, and 21 rats developed a pituitary tumor. When diethylstilbestrol was given 2 days before neutron radiation to 35 rats, the average survival was 239 days; 32 rats developed a total of 842 mammary adenocarcinomas, 1 rat developed a single mammary fibroadenoma, and 34 rats developed a pituitary tumor. All of the 31 control rats survived the 50-week study period, and none developed tumors. Twenty-one of the rats that received both diethylstilbestrol and neutron radiation and 1 rat that received only diethylstilbestrol exhibited a multiple mammary adenocarcinoma response with a range of 18 to 72 mammary adenocarcinomas per rat. These results were interpreted to mean that a synergistic interaction between diethylstilbestrol and neutron radiation on mammary adenocarcinoma formation occurs in terms of an earlier onset and a larger number of mammary adenocarcinomas. These results confirm and complement a previously reported synergistic interaction between diethylstilbestrol and X-radiation on mammary adenocarcinoma formation A x C female rats.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 7332007
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 36:3; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
ELEMENTARY PARTICLES
FERMIONS
GLANDS
HADRONS
HORMONES
IRRADIATION
MAMMALS
MAMMARY GLANDS
NEOPLASMS
NEUTRONS
NUCLEONS
ORGANS
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SYNERGISM
VERTEBRATES