Rat differences in mammary tumor induction with estrogen and neutron radiation. [Diethylstilbestrol]

Journal Article · Fri Dec 01 04:00:00 EST 1978 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6252412

Shellabarger, C J; Stone, J P; Holtzman, S

Young adult female rats of either the Sprague--Dawley stock or the ACI strain were each given an implant of a compressed pellet of 5 mg diethylstilbestrol (DES) and 15 mg cholesterol 2 days before irradiation with 0.4, 1.3, or 4.0 rads of 0.43-MeV neutrons. These rats were studied, along with appropriate irradiated and nonirradiated controls, until death or for a maximum of 48 weeks. Response differences between the strain and stock included the following: DES produced both pituitary tumors and mammary adenocarcinomas (MAC) only. Neutron radiation increased mammary fibroadenoma (MFA) formation in Sprague--Dawley rats only. No interactions between DES and radiation on MAC formation in Sprague--Dawley rats. However, when DES and neutron radiation were combined, DES appeared to inhibit the MFA response to radiation in Sprague--Dawley rats. In contrast, DES appeared to act synergistically with neutron radiation on MAC formation in ACI rats. These results clearly demonstrate rat differences in mammary gland carcinogenesis in response to estrogen, to radiation, or to a combination of both agents.

• Research Organization: Brookhaven National Lab., Upton, NY
• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 6252412
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 61:6; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
550900 -- Pathology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ADENOMAS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
BODY
CARCINOGENESIS
CARCINOMAS
DISEASES
ELEMENTARY PARTICLES
ENERGY RANGE
ESTROGENS
EXTERNAL IRRADIATION
FERMIONS
GENETIC VARIABILITY
GLANDS
HADRONS
HORMONES
IRRADIATION
KEV RANGE
KEV RANGE 100-1000
LOW DOSE IRRADIATION
MAMMALS
MAMMARY GLANDS
NEOPLASMS
NEUTRONS
NUCLEONS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
STEROID HORMONES
SYNERGISM
VERTEBRATES
WHOLE-BODY IRRADIATION