Synergism of estrogens and x-rays in mammary carcinogenesis in female ACI rat

Journal Article · Sat Aug 01 04:00:00 EDT 1981 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5892842

Holtzman, S; Stone, J P; Shellabarger, C J

A previously demonstrated synergistic interaction between diethylstilbestrol (DES) and radiation on rate mammary carcinogenesis was extended to another estrogen, 17-ethinyl-estradiol (EE2). These newly reported results with EE2 demonstrated that the previously reported synergistic interaction between DES and radiation is not confined to just DES. Instead, these new results implied that the synergistic interaction is a synergistic interaction between the estrogenic activity of DES and radiation on rat mammary carcinogenesis. Female inbred ACI rats were used. By the end of the experiment, no neoplasia was detected in rats bearing cholesterol pellets, with an without x-ray exposure. No significant n tumor data were obtained from rats treated with 0.1 mg EE2, with and without x-rays. Approximately 50% of the rats treated with DES and approximately 90% of the rats treated with 1 mg EE2 had 1 or more mammary adenocarcinomas (MAC). X-rays synergistically increased the number of MAC per rat in the groups implanted with DES or 1 mg EE2. X-rays also increased the trend toward earlier increased incidence of rats with MAC as compared to rats treated with estrogens only. All rats treated with DES and 1 mg EE2 had pituitary tumors. The mean weight of the pituitary tumors in the groups treated with 1 mg EE2 was approximately 1.5 times that of the groups treated with DES. Mean terminal plasma prolactin levels for rats treated with 1 mg EE2 or DES were, respectively, 17.5 and 9.5 times control values.

• Research Organization: Brookhaven National Lab., Associated Universities, Upton, NY
• OSTI ID: 5892842
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 67:2; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CHEMISTRY
CHOLESTEROL
DISEASES
ELECTROMAGNETIC RADIATION
ESTROGENS
EXTERNAL IRRADIATION
GLANDS
HORMONES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MAMMARY GLANDS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
STEROID HORMONES
STEROIDS
STEROLS
SYNERGISM
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION