Synergism of diethylstilbestrol and other carcinogens in concurrent development of hepatic, mammary, and pituitary tumors in castrated male rats
Castrated male WF rats, given implants of pellets containing 5.0 mg diethylstilbestrol (DES), were given N-butyl-N-nitrosourea (NBU) in small amounts, which alone produced no mammary tumors in intact female rats. Treatment resulted in the high yield of hepatic tumors (HT), mammary tumors (MT), and pituitary tumors (PT) concurrently in each rat. If animals were further tested with prolactin, the development of HT and MT was accelerated, whereas that of PT was suppressed. None of the intact or castrated rats receiving NBU and/or prolactin developed tumors in any tissues if DES treatment was omitted. Exposure of male rats, preconditioned similarly to NBU treatment, to 200 rads of 14.1-MeV fast-neutron radiation also elicited HT, MT, and PT with an efficiency comparable to that of NBU-treated rats. These findings indicate that DES played an essential role in the whole carcinogenic process in each tissue and that castrated male rats, if conditioned properly with estrogens, are useful for the study of the carcinogenesis mechanism in these tissues.
- Research Organization:
- Hiroshima Univ., Japan
- OSTI ID:
- 5500172
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 65:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ESTROGENS
CARCINOGENESIS
EXTERNAL IRRADIATION
LIVER
BIOLOGICAL RADIATION EFFECTS
MAMMARY GLANDS
PITUITARY GLAND
FAST NEUTRONS
LTH
NEOPLASMS
NITROSO COMPOUNDS
RATS
SYNERGISM
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
ELEMENTARY PARTICLES
ENDOCRINE GLANDS
FERMIONS
GLANDS
GONADOTROPINS
HADRONS
HORMONES
IRRADIATION
MAMMALS
NEUTRONS
NUCLEONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RODENTS
STEROID HORMONES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)