Apparent rat strain related sensitivity of phorbol promotion of mammary carcinogenesis

Journal Article · Sun Jul 01 04:00:00 EDT 1979 · Cancer Res.; (United States)

OSTI ID:5059336

Shellabarger, C J; Holtzman, S; Stone, J P

In an experiment reported here, in female Sprague-Dawley rats, using twice-weekly i.p. injections of 4 mg phorbol for 10 weeks, after a single feeding of 6 mg dimethylbenz(s)anthracene (DMBA) in female Wister rats, it was found that phorbol given after DMBA did not augment mammary adenocarcinoma incidence or lymphatic leukemia incidence as compared to DMBA given alone. It thus appears that there is a strain-related sensitivity between Wistar and Sprague-Dawley rats with regard to the promoting activity of phorbol when phorbol treatment follows DMBA treatment, and mammary adenocarcinoma incidence and lymphatic leukemia incidence are studied. Further, in Sprague-Dawley rats, phorbol did not promote mammary fibroadenoma incidence in DMBA-treated rats, mammary adenocarcinoma incidence in procarbazine-treated rats, and mammary adenocarcinoma incidence or mammary fibroadenoma incidence in x-ray-treated rats. DMBA and procarbazine, with or without phorbol, tended to induce more mammary neoplasms in the thoracic than in the abdominal mammary glands. X-irradiation tended to induce mammary neoplasms in approximately equal numbers in the anterior and posterior mammaryglands. It was suggested that regional differences in chemically induced mammary carcinogenesis were due to a difference in the transport and delivery of the chemical carcinogens to the regions rather than a difference in the amount of mammary gland tissue in the regions. An analysis suggested that the development of a mammary adenocarcinoma fibroadenoma are independent processes.

• Research Organization: Brookhaven National Lab., Upton, NY
• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 5059336
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BODY
CARCINOGENESIS
CARCINOGENS
CARCINOMAS
CONDENSED AROMATICS
CROTON OIL
DIMETHYLBENZANTHRACENE
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ESTERS
GLANDS
HEMIC DISEASES
IONIZING RADIATIONS
LEUKEMIA
LIPIDS
MAMMALS
MAMMARY GLANDS
NEOPLASMS
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
RADIATIONS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SENSITIVITY
SYNERGISM
TOXICITY
TRIGLYCERIDES
VERTEBRATES
X RADIATION