Induction of mammary tumors in aging rats by 7,12-dimethylbenz(a)anthracene: role of DNA synthesis during carcinogenesis

Journal Article · Sat Mar 01 04:00:00 EST 1980 · J. Natl. Cancer Inst.; (United States)

OSTI ID:7097103

Sinha, D K ^[1]; Dao, T L

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1. Roswell Park Memorial Inst., Buffalo, NY

Two routes of administration were used to test the susceptibility of the mammary gland of the rat to 7,12-dimethylbenz(a)anthracene (DMBA) carcinogenesis in relation to age of the tissue. In one series of experiments, 60-, 70-, 90-, 120-, 150-, and 200-day-old female nonbred Sprague-Dawley rats were given DMBA iv. In parallel experiments, rats of the same ages as those above were given DMBA by local application. Mammary tumors developed in 89 to 90% of the 60- and 70-day-old rats and in 40% of the 90-day-old rats. Rats 120 days old and older were completely refractory to DMBA. In contrast, all rats, irrespective of their ages, developed tumors when DMBA was applied locally. DMBA given iv significantly inhibited DNA synthesis in mammary glands, but DMBA applied locally significantly increased the Li of the mammary glands.

• OSTI ID: 7097103
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 64:3; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
AROMATICS
AUTORADIOGRAPHY
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DIMETHYLBENZANTHRACENE
DISEASES
DNA
DNA REPLICATION
GLANDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
MAMMALS
MAMMARY GLANDS
NEOPLASMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
VERTEBRATES