Assessment of the role of oxygen and mitochondria in heat shock induction of radiation and thermal resistance in Saccharomyces cerevisiae

Journal Article · Sat Oct 01 04:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576170· OSTI ID:5527605

Mitchel, R E.J.; Morrison, D P

In response to a heat shock, the yeast Saccharomyces cerevisiae undergoes a large increase in its resistance to heat and, by the induction of its recombinational DNA repair capacity, a corresponding increase in resistance to radiation. Yeast which lack mitochondrial DNA, mitochondria-controlled protein synthetic apparatus, aerobic respiration, and electron transport (rho/sup 0/ strain) were used to assess the role of O/sub 2/, mitochondria, and oxidative processes controlled by mitochondria in the induction of these resistances. We have found that rho/sup 0/ yeast grown and heat shocked in either the presence or absence of O/sub 2/ are capable of developing both radiation and heat resistance. We conclude that neither the stress signal nor its cellular consequences of induced heat and radiation resistance are directly dependent on O/sub 2/, mitochondrial DNA, or mitochondria-controlled protein synthetic or oxidative processes.

• Research Organization: Atomic Energy of Canada Ltd., Chalk River, Ontario
• OSTI ID: 5527605
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 96:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMISTRY
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
CELL CONSTITUENTS
CHEMISTRY
ELECTROMAGNETIC RADIATION
ELEMENTS
ENERGY
FUNGI
HEAT
IONIZING RADIATIONS
MICROORGANISMS
MITOCHONDRIA
NONMETALS
ORGANIC COMPOUNDS
ORGANOIDS
OXYGEN
PLANTS
PROTEINS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SYNTHESIS
X RADIATION
YEASTS