Duodenal ulcerogens, cysteamine, and propionitrile stimulate serum gastrin levels in the rat

Journal Article · Thu Dec 01 04:00:00 EST 1977 · Gastroenterology; (United States)

OSTI ID:5522462

Lichtenberger, L M; Szabo, S; Trier, J S

Cysteamine and propionitrile are members of a family of compounds which induce the formation of acute duodenal ulcers in fasted and fed rats. Gastric acid secretion is increased by both agents, and acid hypersecretion appears to be required for ulcer formation. To determine the role of gastrin in the ulcerogenic mechanism, cysteamine and propionitrile were administered to fasted rats and their effect on fasting and food-stimulated serum gastrin levels was studied. Intragastric administration of cysteamine caused a 3- to 4-fold increase in fasting serum gastrin levels over the values of controls. Propionitrile was a less effective stimulant of gastrin release, causing a 1.5- to 2-fold increase in gastrin levels over matched control rats. The food-stimulated rise in serum gastrin levels after either a chow meal or intragastric instillation of a peptone solution was markedly enhanced by cysteamine pretreatment. Three hours after feeding the serum gastrin levels of cysteamine pretreated rats were 6 times higher than those of feed controls. The high serum gastrin levels of cysteamine-pretreated fed rats could not be explained solely by the additive effects of cysteamine and food, indicating that a potentiating interaction may exist between the two stimulants of gastrin release. The importance of this drug-induced stimulation of gastrin release, under both fasted and fed conditions, in the ulcerogenic process has yet to be ascertained.

• Research Organization: Peter Bent Brigham Hospital, Boston, MA
• OSTI ID: 5522462
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 73:6; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISEASES
DRUGS
FASTING
FEEDING
GASTRIC ACID
GASTRIN
GASTROINTESTINAL TRACT
HORMONES
INTESTINES
MAMMALS
MATERIALS
MEA
NITRILES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SECRETION
SMALL INTESTINE
STIMULI
THIOLS
ULCERS
VERTEBRATES