Biochemical changes in tissue catecholamines and serotonin in duodenal ulceration caused by cysteamine or propionitrile in the rat

Journal Article · Sun Mar 01 04:00:00 EST 1987 · J. Pharmacol. Exp. Ther.; (United States)

OSTI ID:6786625

Szabo, S; Horner, H C; Maull, H; Schnoor, J; Chiueh, C C; Palkovits, M

Previous structure-activity and pharmacologic studies with duodenal ulcerogens cysteamine and propionitrile implicating catecholamines in the pathogenesis of duodenal ulceration have now been followed up by dose- and time-response biochemical investigations to assess the importance of monoamines in the development of duodenal ulcers. The concentrations of norepinephrine (noradrenaline), dopamine, serotonin and their metabolites were measured in total brain, brain regions, stomach, duodenum, pancreas and adrenals in the rat. Turnover of catecholamines was determined in rats pretreated with the inhibitor of tyrosine hydroxylase alpha-methyl-p-tyrosine. The duodenal ulcerogens caused a dose- and time-dependent depletion of norepinephrine in virtually all the tissues examined. The effect was maximal 4 or 7 hr after cysteamine or propionitrile, and norepinephrine levels returned to normal in 24 hr. Dopamine changes were selective and often biphasic, e.g., elevation in adrenals, biphasic in brain cortex, hippocampus and midbrain, but uniformly decreasing in glandular stomach and duodenum. In the median eminence dopamine levels decreased by 181 and 324% at 15 and 30 min, respectively, after cysteamine, but neither dopamine nor 3,4-dihydroxyphenylacetic acid was modified in the periventricular nucleus. Serotonin levels were relatively stable, revealing slight elevations or no changes in most of the tissues. The turnover of norepinephrine was accelerated by both chemicals in virtually all brain regions, but dopamine turnover was affected only in a few areas, e.g., in the corpus striatum and medulla oblongata cysteamine decreased dopamine turnover, whereas propionitrile first (at 1 hr) accelerated then (at 8 hr) significantly suppressed it.(ABSTRACT TRUNCATED AT 250 WORDS)

• Research Organization: Brigham and Women's Hospital, Boston, MA
• OSTI ID: 6786625
• Journal Information: J. Pharmacol. Exp. Ther.; (United States), Journal Name: J. Pharmacol. Exp. Ther.; (United States) Vol. 3; ISSN JPETA
• Country of Publication: United States
• Language: English

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560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATECHOLAMINES
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISTRIBUTION
DOPAMINE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENDOCRINE GLANDS
GASTROINTESTINAL TRACT
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INTESTINES
MAMMALS
MEA
NERVOUS SYSTEM
NEUROREGULATORS
NITRILES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PHENOLS
POLYPHENOLS
PROPIOLONITRILE
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SEROTONIN
SMALL INTESTINE
STOMACH
SYMPATHOMIMETICS
THIOLS
TISSUE DISTRIBUTION
TRYPTAMINES
ULCERS
VERTEBRATES