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Duodenal ulcerogens cysteamine and propionitrile decrease duodenal neutralization of acid in the rat

Journal Article · · Dig. Dis. Sci.; (United States)
DOI:https://doi.org/10.1007/BF01312562· OSTI ID:5743983
; ;
Neutralization of acid was evaluated in rat proximal duodenal segments isolated from biliary and pancreatic secretions. Duodenal ulcerogenic doses of cysteamine produced a significant decrease in acid disposal 0.5-2 hr after treatment. Oral or subcutaneous administration of the duodenal ulcerogen was effective. The potent ulcerogen cysteamine produced a more pronounced decrease than propionitrile (a weak duodenal ulcerogen). The failure of ethanolamine, a nonulcerogenic structural analog of cysteamine to significantly alter acid disposal suggests that the effect is not due to the toxic properties of the duodenal ulcerogen. The results reinforce the concept that the duodenum is able to dispose of significant quantities of acid. The decrease in acid-handling may contribute to duodenal susceptibility to acid after treatment with ulcerogens and possibly reflects pathophysiologic changes early in duodenal ulceration.
Research Organization:
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
OSTI ID:
5743983
Journal Information:
Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 28:8; ISSN DDSCD
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
INTESTINES
MAMMALS
MEA
NITRILES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PH VALUE
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SMALL INTESTINE
THIOLS
ULCERS
VERTEBRATES