Somatostatin in rat tissues is depleted by cysteamine administration

Journal Article · Tue Dec 01 04:00:00 EST 1981 · Endocrinology; (United States)

OSTI ID:5510589

Szabo, S; Reichlin, S

Administration of cysteamine (mercaptoethylamine) induces in rats severe perforating duodenal ulcers. Because the ulcerogenic properties of cysteamine are markedly reduced by treatment with somatostatin, we considered the possibility that cysteamine-induced duodenal ulcer might be mediated by depletion of tissue somatostatin, and thereby of its paracrine influences on gastrin and gastric acid secretion. To test this hypothesis, we measured the concentration of immunoreactive somatostatin (IR-somatostatin) in stomach and duodenal mucosa at intervals after administration of a single ulcerogenic dose (30 mg/kg by stomach tube). IR-somatostatin in these tissues fell rapidly to reach a minimum at 4 h (stomach 31%, duodenum 60% of control respectively). IR-somatostatin in hypothalamus and pancreas decreased gradually to a minimum at 7 h. Another duodenal ulcerogen, propionitrile (10 mg/100 g bw, s.c.) which is more toxic than cysteamine, and several stressful procedures including ether anesthesia, restraint and s.c. formalin did not lower stomach or duodenal IR-somatostatin. Gut, pancreas and hypothalamic VIP levels were not influenced by cysteamine. These findings suggest that cysteamine is a relatively specific depletor of tissue somatostatin. Because blood levels of somatostatin fell, and only trivial amounts of the peptide were found in the stomach lumen after cysteamine administration, it appears likely that this agent acts at the cellular level to cause breakdown of preformed somatostatin and/or to acutely reduce its synthesis.

• Research Organization: Department of Pathology, Brigham and Women's Hospital, Boston, MA
• OSTI ID: 5510589
• Journal Information: Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 109:6; ISSN ENDOA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DRUGS
ENDOCRINE GLANDS
ETHERS
GASTRIC ACID
GASTRIN
GASTROINTESTINAL TRACT
GLANDS
HORMONES
HYPOTHALAMUS
INTESTINES
MAMMALS
MATERIALS
MEA
NERVOUS SYSTEM
NITRITES
NITROGEN COMPOUNDS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PANCREAS
PATHOLOGICAL CHANGES
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SMALL INTESTINE
SOMATOSTATIN
STOMACH
THIOLS
ULCERS
VERTEBRATES