Radioimaging of human ovarian carcinoma xenograft in nude mice

Journal Article · Sun Nov 01 04:00:00 EST 1987 · Gynecol. Oncol.; (United States)

DOI:https://doi.org/10.1016/0090-8258(87)90175-2· OSTI ID:5519711

Manetta, A; Satyaswaroop, P G; Hamilton, T; Ozols, R; Mortel, R

Human ovarian carcinomas in nude mice were radioimaged using a well-characterized antibody against a tumor-associated antigen (CA 125) and three transplantable human ovarian carcinoma tumor lines: NIH:OVCAR 3, NIH:OVCAR 5, and NIH:OVCAR 9. Radioiodinated monoclonal antibody OC125 was used in these studies. In order to establish the optimal conditions for imaging, tumor/blood ratios were determined. Gamma scintigraphy of nude mice bearing subcutaneous transplants of human ovarian carcinomas 3-4 days after /sup 131/I-OC125 administration demonstrated selective localization of the radiolabeled monoclonal antibody by these tumors without need for any background subtraction techniques.

• Research Organization: Pennsylvania State Univ., Hershey
• OSTI ID: 5519711
• Journal Information: Gynecol. Oncol.; (United States), Journal Name: Gynecol. Oncol.; (United States) Vol. 28:3; ISSN GYNOA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARCINOMAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EXPERIMENTAL NEOPLASMS
FEMALE GENITALS
GONADS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MAMMALS
MAN
MICE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
PRIMATES
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SCINTISCANNING
TRANSPLANTS
USES
VERTEBRATES