Therapeutic effect of a radiolabeled monoclonal antibody on human ovarian cancer xenograft in nude mice

Journal Article · Tue Feb 28 23:00:00 EST 1989 · Gynecol. Oncol.; (United States)

DOI:https://doi.org/10.1016/0090-8258(89)90643-4· OSTI ID:6325342

Manetta, A; Satyaswaroop, P G; Hamilton, T; Ozols, R; Mortel, R

The therapeutic value of 131I-OC125, a radiolabeled monoclonal antibody directed against a human ovarian tumor associated antigen CA125, was examined in an ascites forming intraperitoneal human ovarian carcinoma nude mouse model. Nude mice were injected intraperitoneally with NIH:OVCAR3 cells. Twenty-one days after tumor transplantation, groups of animals were injected intraperitoneally as follows: Group 1 with 200 microCi of 131I-OC125 (n = 20), Group 2 with 200 microCi of 131I (n = 17), Group 3 with 200 microCi of 131I-IgG (n = 21), Group 4 with 60 micrograms of OC125 (n = 18), and Group 5 was left untreated (n = 21). Survival of the tumor-bearing animals was used as the endpoint of the experiment. Mean survivals were found to be 52 +/- 18 days for the 131I-OC125 group, 53 +/- 16 days for the 131I-IgG group, 49 +/- 13 days for the 131I group, 47 +/- 24 days for the OC125 group, and 47 +/- 15 days for the untreated control. These results would indicate no therapeutic advantage of 131I-OC125 over controls in this animal model. However, other approaches using single as well as multiple radiolabeled monoclonal antibodies need to be tested in this model in order to definitely establish the efficacy of this treatment modality.

• Research Organization: Univ. of California, Orange (USA)
• OSTI ID: 6325342
• Journal Information: Gynecol. Oncol.; (United States), Journal Name: Gynecol. Oncol.; (United States) Vol. 32:3; ISSN GYNOA
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
ANTIBODIES
ASCITES TUMOR CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BODY
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DISEASES
EXPERIMENTAL NEOPLASMS
FEMALE GENITALS
GONADS
IMMUNOLOGY
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAPERITONEAL INJECTION
IODINE 131
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MICE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SURVIVAL CURVES
THERAPY
TUMOR CELLS
VERTEBRATES