Radioimmunoscintigraphy and radioimmunotherapy of renal cell carcinoma xenografts

Journal Article · Thu Jan 01 00:00:00 EST 1987 · NCI Monogr.; (United States)

OSTI ID:6523877

Vessella, R L; Alvarez, V; Chiou, R K; Rodwell, J; Elson, M; Palme, D; Shafer, R; Lange, P

From a panel of monoclonal antibodies (MAb) reactive with human renal cell carcinoma generated by this laboratory, three (designated A6H, C5H, and D5D) were selected for in vivo studies with a nude mouse xenograft model. These studies included /sup 131/I- and /sup 111/In-labeled MAb radioimmunoscintigraphy and /sup 131/I-labeled MAb radioimmunotherapy. In the imaging studies, these radiolabeled MAb allowed visualization of subcutaneous xenografts larger than 40 mg and subrenal capsule xenografts smaller than 20 mg. Comparisons of tumor to non-tumor tissue radiolabel distribution yielded unusually high ratios and depended on the MAb-xenograft combination. The /sup 111/In-radiolabeled A6H showed increased accumulation in the liver compared with /sup 131/I-A6H, but this still did not necessitate background subtraction for good visualization of small, subrenal capsule renal cell carcinoma xenografts. Radioimmunotherapy studies with /sup 131/I-A6H in BALB/c nu/nu mice bearing established renal cell carcinoma xenografts showed a prolonged (greater than 90 days) regression in tumor burden and possible cures, whereas three sets of control mice showed progressive and rapid increases in tumor size. These studies indicated that MAb, which show good tissue biodistribution and high imaging sensitivity, could also be capable of delivering effective radiotherapy to the tumor when human equivalent radiolabeled-MAb doses are used.

• Research Organization: Veterans Administration Medical Center, Minneapolis, MN
• OSTI ID: 6523877
• Journal Information: NCI Monogr.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
DIAGNOSIS
RADIOIMMUNOTHERAPY
KIDNEYS
SCINTISCANNING
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
THERAPEUTIC USES
INDIUM 111
IODINE 131
LIVER
MAN
MICE
TISSUE DISTRIBUTION
TRANSPLANTS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
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DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
IMMUNOLOGY
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOIMMUNOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
USES
VERTEBRATES
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