Study of the diagnosis and treatment of renal cell carcinoma using monoclonal antibodies
Among the potential applications of monoclonal antibodies (Mabs) in the diagnosis and treatment of human cancer is the use in the specific detection of cancer sites and the selective destruction of cancer cells. Fetal kidney was used as an immunogen to develop Mab A6H, which is highly reactive to 16/16 renal cell carcinoma (RCC) cell lines and to 16/19 human RCC specimens. RCC xenografts as small as 40 mg have been imaged clearly in radioimmunoscintigraphy studies using A6H labeled with iodine-131. In Mab-targeted radiotherapy studies, 2 doses of 100-150 uCi /sup 131/I-labeled A6H or an /sup 131/ I-labeled A6H-C5H cocktail caused tumor regression or tumor growth arrest in >80% of treated mice, while no such effect was observed in mice treated with /sup 131/I-labeled control Mab or unlabeled A6H. Internal radiation dosimetry, which was calculated by computer analysis of sequential radioimmunoscintigraphy, showed that A6H delivered approximately 35 rad/uCi of the injected dose to RCC xenografts. When the radiation dose to the tumor was <2500 rad, stabilization in tumor growth was not observed. Radiation doses >3000 rad resulted in tumor regression or growth arrest in >85% of mice. A clinical trial using /sup 131/I-labeled A6H in the diagnosis and treatment of RCC is now underway at our institution.
- Research Organization:
- Minnesota Univ., Minneapolis (USA)
- OSTI ID:
- 7140230
- Country of Publication:
- United States
- Language:
- English
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550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOSES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MEDICINE
MICE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DOSES
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SCINTISCANNING
THERAPEUTIC USES
THERAPY
TRANSPLANTS
USES
VERTEBRATES