Nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
Genomic and cDNA clones for the human nerve growth factor receptor have been used in conjunction with somatic cell hybrid analysis and in situ hybridization to localize the nerve growth factor receptor locus to human chromosome region 17q12-q22. Additionally, part, if not all, of the nerve growth factor receptor locus is present on the translocated portion of 17q (17q21-qter) from a poorly differential acute leukemia in which the chromosome 17 breakpoint was indistinguishable cytogenetically from the 17 breakpoint observed in the t(15;17)(q22;q21) translocation associated with acute promyelocytic leukemia. Thus the nerve growth factor receptor locus may be closely distal to the acute promyelocytic leukemia-associated chromosome 17 breakpoint at 17q21.
- Research Organization:
- Wistar Institute of Anatomy and Biology, Philadelphia, PA
- OSTI ID:
- 5514628
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 83:5; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL GROWTH
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DNA
GENETIC MAPPING
GROWTH
HEMIC DISEASES
HYBRIDIZATION
ISOTOPES
LABELLED COMPOUNDS
LEUKEMIA
LIGHT NUCLEI
MAPPING
MEMBRANE PROTEINS
NEOPLASMS
NERVES
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
OLIGONUCLEOTIDES
ORGANIC COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
RECEPTORS
RECOMBINANT DNA
TRITIUM COMPOUNDS
TUMOR CELLS
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL GROWTH
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DNA
GENETIC MAPPING
GROWTH
HEMIC DISEASES
HYBRIDIZATION
ISOTOPES
LABELLED COMPOUNDS
LEUKEMIA
LIGHT NUCLEI
MAPPING
MEMBRANE PROTEINS
NEOPLASMS
NERVES
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
OLIGONUCLEOTIDES
ORGANIC COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
RECEPTORS
RECOMBINANT DNA
TRITIUM COMPOUNDS
TUMOR CELLS