The orphan nuclear receptor ROR{alpha} (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9

Journal Article · Thu Aug 10 04:00:00 EDT 1995 · Genomics

DOI:https://doi.org/10.1006/geno.1995.1197· OSTI ID:390690

Giguere, V ^[1]; Beatty, B; Squire, J ^[2]

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1. McGill Univ., Montreal (Canada)
2. Hospital for Sick Children, Toronto (Canada); and others

ROR{alpha} is a novel member of the steroid/thyroid/retinoid receptor superfamily with unique DNA-binding properties. We have mapped the RORA gene by fluorescence in situ hybridization to human chromosome 15q21-q22. To map the mouse Rora gene, a partial mouse cDNA clone was isolated from brain. Using interspecific backcross analysis, we have mapped the Rora gene to mouse chromosome 9. This places the human RORA gene in the proximity of the PML gene, which is involved in a reciprocal chromosomal translocation t(15:17) with the RARA gene in patients with acute promyelocytic leukemia. 13 refs., 2 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 390690
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 28; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACID SEQUENCE
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
FLUORESCENCE
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 15
HUMAN CHROMOSOME 17
MICE
MYELOID LEUKEMIA
PATIENTS
RECEPTORS
STEROID HORMONES
TRANSCRIPTION
TRANSCRIPTION FACTORS