Chromosomal localization of mouse bullous pemphigoid antigens, BPAG1 and BPAG2: Identification of a new region of homology between mouse and human chromosomes

Journal Article · Fri Jan 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1027· OSTI ID:6697312

Copeland, N G; Gilbert, D J; Jenkins, N A ^[1]; Li, K; Sawamura, D; Chu, Monli; Uitto, J ^[2]; Giudice, G J ^[3]

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1. NCI-Frederick Cancer Research and Development Center, MD (United States)
2. Jefferson Medical College, Philadelphia, PA (United States)
3. Medical College of Wisconsin, Milwaukee (United States)

Two bullous pemphigoid antigens, BPAG1 and BPAG2, have been recently cloned and mapped to human chromosomes 6p12-p11 and 10q24.3, respectively. In this study, we localized the corresponding mouse genes by interspecific backcross analysis. Bpag-1 mapped to the proximal region of mouse chromosome 1, identifying a new region of homology between human chromosome 6 and mouse chromosome 1. Bpag-2 mapped to the distal end of mouse chromosome 19 in a region of homology to human chromosome 10q. These assignments confirm and extend the relationships between the human and the mouse chromosomes. 13 refs., 1 fig.

• OSTI ID: 6697312
• Journal Information: Genomics; (United States), Vol. 15:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIGENS
GENETIC MAPPING
HUMAN CHROMOSOMES
ANTIBODIES
BLOOD CIRCULATION
CHROMOSOMES
GENES
IMMUNOGLOBULINS
MICE
ANIMALS
GLOBULINS
MAMMALS
MAPPING
ORGANIC COMPOUNDS
PROTEINS
RODENTS
VERTEBRATES
550400* - Genetics