Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q13.1
- Jackson Lab., Bar Harbor, ME (United States)
- ABL-Basic Research Program, Frederick, MD (United States); and others
Mybl2 encodes a transcription factor that is though to play an important role in cell cycle progression. Here we report the chromosomal localization of Mybl2 in mouse and human. Using mouse Mybl2 cDNA clones as probes, we assigned Mybl2 in an interspecific backcross panel to distal Chromosome 2. Using human cDNA probes in combination with FISH analysis, we localized MYBL2 to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders. Both chromosomal regions are highly homologous, and the map positions, therefore, confirm each other. However, our findings are in contrast to a previous report by Barletta et al. that placed the MYBL2 gene on human chromosome Xq.13. 21 refs., 2 figs.
- OSTI ID:
- 466002
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 35; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
ANIMAL CELLS
CELL CYCLE
CELL PROLIFERATION
CHROMOSOMAL ABERRATIONS
DNA HYBRIDIZATION
DNA-CLONING
ELECTROPHORESIS
FLUORESCENCE
GENE REGULATION
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
IN-SITU HYBRIDIZATION
MAN
MICE
MYELOID LEUKEMIA
PROBES
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSCRIPTION
TRANSCRIPTION FACTORS