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Investigation of adenylic nucleotide levels in the rat spleen under normal conditions and following x irradiation

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5512182
;
According to the data of a number of authors, depression of mitochondrial and nuclear oxidative phosphorylation is demonstrable in radiosensitive tissues (thymus, spleen) in the first hours after exposure to radiation in doses of 50 to 100 rad. We previously also demonstrated that the levels of adenylic nucleotides in submaxillary lymph nodes and thymus of irradiated rats do not change appreciably 15 min and 1 h after delivery of 1000 rad radiaton. In the opinion of some authors, depression of energetic processes may play a decisive role in the mechanism of early postradiation death of cellular elements in radiosensitive tissues. The objective here was to examine the levels of adenylic nucleotides in the spleen of rats at the early postradiation stage.
Research Organization:
Central Scientific Research Inst. of Roentgenology and Radiology, Leningrad, USSR
OSTI ID:
5512182
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:5; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENYLIC ACID
ADP
AMP
ANIMALS
ATP
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CONSTITUENTS
CELL NUCLEI
CHEMICAL REACTIONS
DATA
DATA FORMS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MITOCHONDRIA
NUCLEOTIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHORYLATION
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SPLEEN
TABLES
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION