Effect of ozone on the agglutination of erythrocytes by concanavalin A. II. Study of human subjects receiving supplemental vitamin E

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · Environ. Res.; (United States)

OSTI ID:5510994

Hamburger, S J ^[1]; Goldstein, B D; Buckley, R D; Hackney, J D; Amoruso, M A

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1. New York Univ. Medical Center, NY

Studies of the effect of ozone on the response of human erythrocytes to concanavalin A revealed a decrease in agglutinability following in vitro exposure (1 ppM ozone x 30 min) similar to that previously observed in rat erythrocytes. Incubation of human erythrocytes with malonaldehyde, an oxidation product of polyunsaturated fatty acids, also resulted in decreased agglutination by concanavalin A. Red cells obtained from 29 subjects receiving either vitamin E (800 IU) or a placebo daily were examined before and after the subjects were exposed to 0.5 ppM ozone for 2 h. A tendency toward a decrease in agglutinability by concanavalin A following ozone exposure was present in the red cells of those subjects not receiving supplemental vitamin E. However, the results were not statistically significant.

• OSTI ID: 5510994
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 19:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
ERYTHROCYTES
ESTERS
IN VITRO
INCUBATION
LECITHINS
LIPIDS
MAMMALS
MAN
MATERIALS
METABOLISM
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
OZONE
PHOSPHOLIPIDS
PRIMATES
TOLERANCE
TOXICITY
VERTEBRATES
VITAMINS