Effect of ozone on the agglutination of erythrocytes by concanavalin A. I. Studies in rats. [Rats, tritium]
A decrease in the agglutination of rat erythrocytes by the lectin concanavalin A was observed after in vitro exposure to ozone (1 ppM for 2 h) and after inhalation of 0.5 to 2.0 ppM ozone for 2 h. Agglutination was inhibited by ..cap alpha..-methyl-D-mannopyrannoside demonstrating that it is specific for the lectin. Studies with radioactive concanavalin A indicated that ozone exposure did not significantly affect the number of membrane sites available for lectin binding. Further studies revealed that erythrocytes incubated with malonaldehyde, a decomposition product of lipid peroxidation, also showed a decrease in agglutination as did erythrocytes obtained from rats injected with the oxidizing agent, acetylphenylhydrazine. These findings are consistent with a possible causal role for malonaldehyde in mediating extrapulmonary effects observed after ozone exposure.
- Research Organization:
- New York Univ. Medical Center, NY
- OSTI ID:
- 5406940
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 19:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DOSES
ERYTHROCYTES
ESTERS
HYDRAZIDES
HYDROGEN ISOTOPES
INCUBATION
INHALATION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LECITHINS
LIGHT NUCLEI
LIPIDS
LUNGS
MAMMALS
MATERIALS
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OZONE
PHOSPHOLIPIDS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
TOLERANCE
TOXICITY
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES