Effect of ozone and nitrogen dioxide on the agglutination of rat alveolar macrophages by concanavalin A
In vitro exposure of rat alveolar macrophages to 0.5 ppM ozone for 60 minutes results in a 76% decrease in agglutination by concanavalin A. A decrease in the agglutinability of rat alveolar macrophages by concanavalin A was also observed following inhalation of 0.5 or 1.0 ppM ozone for two hours. In contradistinction, in vitro exposure of rat alveolar macrophages to 2.4 ppM nitrogen dioxide for 60 minutes produced a 64% increase in agglutination by concanavalin A, and increased agglutinability was also noted following inhalation of 12.1 ppM nitrogen dioxide for two hours. Agglutination was almost completely inhibited by alpha-methyl-mannose. Neither pollutant significantly altered the binding of /sup 3/H-concanavalin A to rat alveolar macrophages. These two air pollutants, both of which are known to potentiate respiratory tract infections, appear to affect the response of the alveolar macrophage membrane to concanavalin A in a dissimilar fashion.
- Research Organization:
- New York Univ. Medical Center, NY
- OSTI ID:
- 5112781
- Journal Information:
- Life Sci.; (United States), Vol. 21:11
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
OZONE
ANTIGEN-ANTIBODY REACTIONS
CELL MEMBRANES
GLOBULINS
IN VITRO
INHALATION
LUNGS
MACROPHAGES
MANNOSE
METHYL RADICALS
RATS
TRITIUM COMPOUNDS
ALDEHYDES
ALKYL RADICALS
ANIMAL CELLS
ANIMALS
BODY
CARBOHYDRATES
CELL CONSTITUENTS
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
HEXOSES
INTAKE
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
MONOSACCHARIDES
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTES
PROTEINS
RADICALS
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
SOMATIC CELLS
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
550200 - Biochemistry