Effect of ozone and nitrogen dioxide on the agglutination of rat alveolar macrophages by concanavalin A
In vitro exposure of rat alveolar macrophages to 0.5 ppM ozone for 60 minutes results in a 76% decrease in agglutination by concanavalin A. A decrease in the agglutinability of rat alveolar macrophages by concanavalin A was also observed following inhalation of 0.5 or 1.0 ppM ozone for two hours. In contradistinction, in vitro exposure of rat alveolar macrophages to 2.4 ppM nitrogen dioxide for 60 minutes produced a 64% increase in agglutination by concanavalin A, and increased agglutinability was also noted following inhalation of 12.1 ppM nitrogen dioxide for two hours. Agglutination was almost completely inhibited by alpha-methyl-mannose. Neither pollutant significantly altered the binding of /sup 3/H-concanavalin A to rat alveolar macrophages. These two air pollutants, both of which are known to potentiate respiratory tract infections, appear to affect the response of the alveolar macrophage membrane to concanavalin A in a dissimilar fashion.
- Research Organization:
- New York Univ. Medical Center, NY
- OSTI ID:
- 5112781
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 21:11; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ALKYL RADICALS
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CELL CONSTITUENTS
CELL MEMBRANES
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
GLOBULINS
HEXOSES
IN VITRO
INHALATION
INTAKE
LABELLED COMPOUNDS
LUNGS
MACROPHAGES
MAMMALS
MANNOSE
MEMBRANES
METHYL RADICALS
MONOSACCHARIDES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PHAGOCYTES
PROTEINS
RADICALS
RATS
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
SOMATIC CELLS
TRITIUM COMPOUNDS
VERTEBRATES