Human biochemical response to ozone and vitamin E

Journal Article · Thu Nov 01 04:00:00 EST 1979 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397909529813· OSTI ID:5565816

Posin, C I; Clark, K W; Jones, M P; Buckley, R D; Hackney, J D

To determine whether vitamin E (dl-..cap alpha..-tocopherol) supplementation of the diet provides protection from inhaled oxidants such as ozone (O/sub 3/) in community air pollution, its effects were studied in healthy adult volunteers. Experimental groups received 800 or 1600 IU of vitamin E for 9 weeks or more; control groups received placebos. Double-blind conditions were maintained throughout the study. Biochemical parameters studied included red blood cell fragility; hematocrit and hemoglobin values; red cell glutathione concentration; and the enzymes acetylcholinesterase, glucose-6-phosphate dehydrogenase, and lactic acid dehydrogenase. No significant differences between the responses of the supplemented and placebo groups to a controlled O/sub 3/ exposure (0.5 ppM for 2 h) were found for any of these parameters. The results indicate that vitamin E supplementation in humans, at the levels employed in this experiment, gives no added protection against blood biochemical effects of O/sub 3/ in intermittently exercising subjects under exposure conditions simulating summer ambient air pollution episodes.

• Research Organization: Rancho Los Amigos Hospital, Downey, CA
• OSTI ID: 5565816
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 5:6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

552000 -- Public Health
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AIR POLLUTION
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
DEHYDROGENASES
DIET
DOSE-RESPONSE RELATIONSHIPS
EARTH ATMOSPHERE
ENVIRONMENTAL EFFECTS
ENZYMES
ERYTHROCYTES
ESTERASES
GLOBIN
GLUTATHIONE
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROLASES
KINETICS
LACTATE DEHYDROGENASE
MAMMALS
MAN
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
OZONE
PEPTIDES
PIGMENTS
POLLUTION
POLYPEPTIDES
PORPHYRINS
PRIMATES
PROTEINS
QUANTITY RATIO
REACTION KINETICS
RESPONSE MODIFYING FACTORS
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS