Biochemical changes in humans upon exposure to ozone and exercise

Technical Report · Wed Aug 01 04:00:00 EDT 1979

OSTI ID:5662464

Chaney, S; DeWitt, P; Blomquist, W; Muller, K; Bruce, R

A total of 44 human subjects were exposed to 784 micrograms/cu.m.(0.4 ppm) ozone and 30 human subjects were exposed to air as controls. A four hour exposure was given on each of five consecutive days. Half of each group received a higher level of treadmill exercise than the other half. Nine biochemical blood parameters were measured pre and post exposure: red blood cell glutathione reductase, vitamin E, red blood cell cholinesterase, red blood cell glucose-6-phosphate dehydrogenase, lactic acid dehydrogenase, complement C3, and IgM. Of these variables only vitamin E, red blood cell glucose-6-phosphate dehydrogenase, and complement C3 showed significant changes due to treatment.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 5662464
• Report Number(s): PB-80-105554
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ANALYSIS
CHOLINESTERASE
COMPLEMENT
DEHYDROGENASES
ENZYMES
ERYTHROCYTES
ESTERASES
EXERCISE
HYDROLASES
MATERIALS
OXIDOREDUCTASES
OZONE
POLLUTION
VITAMIN E
VITAMINS