Role of endogenous substances in creating a background of enhanced radioresistance. Report 10. The nature of differences in radioresistance of yeast cells (experiments on Pichia guilliermondii varying in ploidy). [uv and x rays]

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5503947

Goncharenko, E N; Gorskaya, T G; Gudz, T I; Gurovich, A V; Zolotareva, L T; Kaplya, S A; Peshkova, E I

The different components of the biochemical background of radioresistance of yeast cells varying in resistance to radiation were examined, within the framework of a single species, and differing only in set of chromosomes. Pichia guilliermondii, in which, according to various data, radiosensitivity of cells with a diploid set of chromosomes is about twice as high as in cells with a haploid set was used. The levels of biogenous amines, hydroperoxides, and SOD activity were studied. The serotonin and histamine content of the more radioresistant haploid cells was found to be higher than the amine content of diploid cells. The more radioresistant haploid cells also demonstrated a decline of hydroperoxides of free fatty acids and high SOD activity. Thus, radioresistant yeast cells of this species are characterized by higher amounts of biologically active substances with radioprotective properties (biogenous amines and SOD) and lower levels of substances capable of exerting a radiosensitizing effect on the organism (hydroperoxides, the products of oxidation of higher unsaturated fatty acids). The aggregate of data warrants the conclusion that biologically active substances that have radioprotective and radiosensitizing properties are components of the endogenous biochemical background, both in the case of modified and different natural resistance of yeast cells to ionizing radiation. (ERB)

• Research Organization: Moscow State Univ., USSR
• OSTI ID: 5503947
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:2; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
EXPERIMENTAL DATA
FUNGI
HETEROCYCLIC COMPOUNDS
HISTAMINE
HYDROXY COMPOUNDS
IMIDAZOLES
INDOLES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEROXIDES
PLANTS
PLOIDY
PYRROLES
QUANTITY RATIO
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
SEROTONIN
SURVIVAL TIME
SYMPATHOMIMETICS
TRYPTAMINES
ULTRAVIOLET RADIATION
X RADIATION
YEASTS