Osteosarcomas among beagles exposed to /sup 239/Pu
Journal Article
·
· Radiat. Res.; (United States)
A Weibull distribution was fit to the osteosarcoma death times of beagles given single intravenous injections of /sup 239/Pu. For injected doses in the range 0-1..mu..Ci/kg the osteosarcoma incidence rate h(t) at t days after injection can be fit by a quadratic function of injected dose d: h(t) = 2.61 X 10/sup -18/ d/sup 2/t/sup 4.91/. The best-fitting linear function was rejected by the data (P < 0.001). A different formula for h(t), derived from a multistage theory for osteosarcoma induction, was also fit to these data. For this purpose microdosimetry calculations were used to estimate the dose to the cells at risk in the endosteal layer (endosteal dose). According to the best fit, h(t) is a quadratic function of endosteal dose at low doses. A linear dose-response relationship was again rejected. The absence of a linear component at low doses might be explained by the fact that 108 of the 185 animals injected at the lowest doses (<0.02 ..mu..Ci/kg) were still alive at the time these data were collected.
- Research Organization:
- Stanford Univ., CA
- OSTI ID:
- 5500059
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 90:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Osteosarcomas among beagles exposed to /sup 239/Plutonium. Technical report No. 34
Effect of dose level on skeletal retention of /sup 239/Pu(IV) in the beagle
Microdistribution and retention of injected /sup 239/Pu on trabecular bone surfaces of the beagle: implications for the induction of osteosarcoma
Technical Report
·
Fri Feb 29 23:00:00 EST 1980
·
OSTI ID:5482771
Effect of dose level on skeletal retention of /sup 239/Pu(IV) in the beagle
Journal Article
·
Mon Feb 28 23:00:00 EST 1977
· Radiat. Res.; (United States)
·
OSTI ID:7306665
Microdistribution and retention of injected /sup 239/Pu on trabecular bone surfaces of the beagle: implications for the induction of osteosarcoma
Journal Article
·
Tue Jul 01 00:00:00 EDT 1980
· Radiat. Res.; (United States)
·
OSTI ID:5129062
Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CONNECTIVE TISSUE
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EVEN-ODD NUCLEI
HAZARDS
HEALTH HAZARDS
HEAVY NUCLEI
IRRADIATION
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MORTALITY
NEOPLASMS
NUCLEI
OSTEOSARCOMAS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIOINDUCTION
RADIOISOTOPES
RISK ASSESSMENT
SARCOMAS
SKELETAL DISEASES
TISSUES
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CONNECTIVE TISSUE
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EVEN-ODD NUCLEI
HAZARDS
HEALTH HAZARDS
HEAVY NUCLEI
IRRADIATION
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MORTALITY
NEOPLASMS
NUCLEI
OSTEOSARCOMAS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIOINDUCTION
RADIOISOTOPES
RISK ASSESSMENT
SARCOMAS
SKELETAL DISEASES
TISSUES
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES