Osteosarcomas among beagles exposed to /sup 239/Plutonium. Technical report No. 34
A Weibull distribution was fit to the osteosarcoma death times of beagles given single intravenous injections of /sup 239/Pu. For injected doses in the range 0 to 1 ..mu..Ci/kg the osteosarcoma incidence rate h(t) at t days after injection can be fit by a quadratic function of the injected dose. The best fitting linear function was rejected by the data (p < 0.001). A different formula for h(t), derived from amultistage theory for osteosarcoma induction, was also fit to these data. For this purpose microdosimetry calculations were used to estimate the dose to the cells at risk in the endosteal layer (endosteal dose). According to the best fit, h(t) is a quadratic function of endosteal dose at low doses. A linear dose-response relationship was agan rejected. The absence of a linear component at low doses might be explained by the fact that 108 of the 185 animals injected at the lowest doses (< 0.02 ..mu..Ci/kg) were still alive at the time these data were collected.
- Research Organization:
- Stanford Univ., CA (USA). Dept. of Statistics
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 5482771
- Report Number(s):
- DOE/EV/02874-68
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CARCINOGENESIS
CONNECTIVE TISSUE
DATA
DATA FORMS
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSIMETRY
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GRAPHS
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
MAMMALS
MATHEMATICS
MICRODOSIMETRY
MORTALITY
NEOPLASMS
NUCLEI
NUMERICAL DATA
ORGANS
OSTEOSARCOMAS
PATHOGENESIS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
SARCOMAS
SINGLE INTAKE
SKELETAL DISEASES
SKELETON
STATISTICS
TABLES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CARCINOGENESIS
CONNECTIVE TISSUE
DATA
DATA FORMS
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSIMETRY
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GRAPHS
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
MAMMALS
MATHEMATICS
MICRODOSIMETRY
MORTALITY
NEOPLASMS
NUCLEI
NUMERICAL DATA
ORGANS
OSTEOSARCOMAS
PATHOGENESIS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
SARCOMAS
SINGLE INTAKE
SKELETAL DISEASES
SKELETON
STATISTICS
TABLES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES