Effect of dose level on skeletal retention of /sup 239/Pu(IV) in the beagle

Journal Article · Mon Feb 28 23:00:00 EST 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574657· OSTI ID:7306665

Stover, B J ^[1]; Atherton, D R; Stevens, W; Buster, D S; Bruenger, F W

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1. Univ. of North Carolina, Chapel Hill

When /sup 239/Pu(IV) is injected intravenously, its fractional retention in the skeleton of the beagle decreases and then approaches an approximately constant value. The initial fractional deposition of /sup 239/Pu is independent of dose level, but the long term fractional retention is less at the lower dose levels (0.0055 to 0.095 ..mu..Ci/kg) than at the high dose levels (0.30 to 2.9 ..mu..Ci/kg). These findings are in contrast with results on the retention of /sup 239/Pu(IV) in the liver of the beagle. The rate of decrease in hepatic retention of /sup 239/Pu diminishes with decreasing dose level. These opposing effects result from cellular necrosis which is an effect of the ..cap alpha.. irradiation from /sup 239/Pu. Skeletal retention equations are presented for each of the three higher dose levels of /sup 239/Pu and for the group of lower dose levels. These equations and those previously reported for the liver are used to calculate cumulative average radiation doses to the skeleton including marrow, and to the liver throughout the observed lives of the beagles, which were injected in young adulthood at six dose levels of /sup 239/Pu(IV) ranging from 0.016 to 2.9 ..mu..Ci/kg. In the skeletal dose calculations an experimentally determined value of (7.5 +- 1.0) percent for skeletal weight relative to body weight at injection is used. The concentration of plutonium in plasma has been measured from 1 min to 12.5 years following injection. A sum of four exponentials has been fit to the data. Samples were obtained from dogs at six dose levels, and from well, ill, and terminal dogs.

• OSTI ID: 7306665
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BODY
DEPOSITION
DIGESTIVE SYSTEM
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
NUCLEI
ORGANS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
SKELETON
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES