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Effect of dietary carbohydrate on superoxide dismutase in copper deficient rats

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5492936
;

A 31 day study was conducted to examine the effects of carbohydrate type on Cu deficiency. Male rats (n = 36) were fed Cu-deficient (Cu-: < 0.6 ppm) or Cu-adequate (Cu+: 8.2 ppm) diets which contained fructose, sucrose, or cornstarch. Heart and liver Cu levels were elevated in Cu- rats and tended to be highest in Cu- rats fed fructose. Hemoglobin levels of Cu- rats fed fructose, sucrose, and cornstarch were 30%, 17%, and 8%, respectively, lower than Cu+ rats. The dietary treatments markedly affected the metabolism of Cu in the liver and to a lesser extent in the heart. In Cu- rats, Cu levels and Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity in the heart were 29% and 71%, respectively, of the Cu+ rats. Cu levels and Zn,Cu-SOD activity in the livers of Cu- rats were only 15% and 28%, respectively, of Cu+ rats. Furthermore, Cu- rats fed fructose or sucrose had approx. 50% less Cu in the liver compared to Cu- rats fed cornstarch. Both liver Zn,Cu-SOD activity (r = 0.484, p < 0.05) and liver Cu levels (r = 0.668, p < 0.002) were positively correlated to hemoglobin levels to hemoglobin levels in Cu- rats. Thus, it appears that reduced Cu levels in the liver and changes in liver Zn,Cu-SOD activity may be related to the increased severity of Cu deficiency in rats fed simple sugars.

Research Organization:
Univ. of Georgia, Athens
OSTI ID:
5492936
Report Number(s):
CONF-8604222-
Journal Information:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COPPER
DIET
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
GLOBIN
HEART
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LIVER
MAMMALS
METABOLISM
METALS
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PIGMENTS
PORPHYRINS
PROTEINS
RATS
RODENTS
SUPEROXIDE DISMUTASE
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES