Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effects of dietary carbohydrate on iron metabolism and cytochrome oxidase activity in copper-deficient rats

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5381840
;

The effects of dietary carbohydrate on the metabolism of iron and the activity of cytochrome oxidase were examined in Cu-deficient and Cu-adequate rats. Male rats (n = 36) were fed one of six diets which varied in copper level (Cu-: < 0.6 ppm or Cu+: 8.2 ppm) and carbohydrate type (cornstarch, sucrose or fructose). After 31 days, Cu- rats had 50% more iron in the liver and 38, 30 and 18% less iron in the tibia, spleen and kidneys, respectively, than Cu+ rats. The activity of cytochrome oxidase in the bone marrow, heart, and liver were 59%, 51%, and 43%, respectively, of the levels in Cu/sup +/ rats. The type of dietary carbohydrate significantly affected the development of anemia during copper deficiency. Cu-rats fed cornstarch, sucrose or fructose had hematocrit levels which were 92, 83 or 73%, respectively, of Cu+ rats. Similarly, the levels of iron in the tibias of Cu- rats fed cornstarch, sucrose or fructose were 69, 66 or 54%, respectively, of Cu+ rats. The hematocrit levels of Cu- rats were positively correlated to both tibia iron levels (r = 0.64, p < 0.005) and liver cytochrome oxidase activities (r = 0.50, p < 0.05). Thus, it appears that changes in the metabolism of iron may be involved with the development of anemia in Cu- rats fed fructose or sucrose.

Research Organization:
Univ. of Georgia, Athens
OSTI ID:
5381840
Report Number(s):
CONF-8604222-
Journal Information:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
Country of Publication:
United States
Language:
English

Similar Records

Effect of dietary carbohydrate on superoxide dismutase in copper deficient rats
Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:5492936
Consequences of copper (Cu) deficiency are not differentially influenced by fructose or starch in growing pigs fed a dried skim milk-based diet
Journal Article · Wed Feb 08 23:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA) · OSTI ID:7190437
Lack of interaction between dietary fructose and zinc (Zn) nutriture in rats
Journal Article · Tue Mar 04 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:7024476

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL TISSUES
BLOOD COUNT
BODY
BONE MARROW
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
COPPER
DIET
DIGESTIVE SYSTEM
DISACCHARIDES
DISEASES
ELEMENTS
ENZYME ACTIVITY
ENZYMES
FRUCTOSE
GLANDS
HEART
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HEXOSES
IRON
KETONES
LIVER
METABOLISM
METALS
MONOSACCHARIDES
NUTRITIONAL DEFICIENCY
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
SACCHARIDES
SACCHAROSE
SKELETON
SPLEEN
SYMPTOMS
TIBIA
TISSUES
TOXICITY
TRANSITION ELEMENTS