Respiratory response of guinea pigs to oil mists

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298667991430145· OSTI ID:5486712

Costa, D L; Amdur, M O

Respiratory function was measured in guinea pigs exposed for one hour to submicrometer oil mists. Five oils were used: medicinal grade mineral oil, laboratory grade paraffin oil, light lubricating oil, unused motor oil and used motor oil. The last three oils were also studied after having been reacted with sulfur dioxide. No alterations were produced by exposure to any of the oils at concentations of 10 or 40 mg/m/sup 3/. At concentrations above 200 mg/m/sup 3/ both the reacted and unreacted light lubricating oil caused a decrease in compliance which remained throughout the post exposure period. Although the average flow-resistance of the group was increased by the unreacted unused motor oil and by the reacted used motor oil, the variation in response was too great to make this response statistically significant. The fact that reaction of the oils with sulfur dioxide did not increase irritant action indicates that the reaction products with sulfur dioxide are not acutely irritant.

• Research Organization: Harvard School of Public Health, Boston, MA
• OSTI ID: 5486712
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 40:8; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020900 -- Petroleum-- Environmental Aspects
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALKANES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
CHEMICAL REACTIONS
COLLOIDS
COMPARATIVE EVALUATIONS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
GUINEA PIGS
HYDROCARBONS
INHALATION
INTAKE
LUBRICANTS
LUNGS
MAMMALS
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PETROLEUM PRODUCTS
RESPIRATION
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SOLS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TOXICITY
VERTEBRATES
WASTE OILS