Comparison of gas clearance and radioactive microspheres for pancreatic blood flow measurement

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Pancreas; (USA)

DOI:https://doi.org/10.1097/00006676-198904000-00004· OSTI ID:5473327

DeMar, A R; Graham, L S; Lake, R; Fink, A S ^[1]

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1. Sepulveda Veterans Administration Medical Center, CA (USA)

Measurement of pancreatic blood flow (PBF) is technically demanding. Although radiolabeled microspheres are considered the gold standard for PBF assessment, they have practical limitations. In the current study, H{sub 2} and xenon-133 gas clearance techniques were adapted to PBF measurement and compared to radiolabeled microsphere techniques. Simultaneous measurements of PBF were made using either hydrogen or xenon gas washout and radiolabeled microspheres. Measurements were made under basal, vasoconstricted (vasopressin 2U i.v. or nicotine 4 micrograms/kg/h) and stimulated (secretin 125 ng/kg/h or 2 U/kg i.v.) conditions (random order). Mean PBF was 26.9 +/- 5.3, 50.5 +/- 2.3 and 27.6 +/- 5.2 ml/min/100 g basally, 36.9 +/- 8.0, 90.1 +/- 18.9, and 81.7 +/- 14.5 ml/min/100 g in the stimulated state, and 24.2 +/- 7.8, 25.0 +/- 3.5, and 14.9 +/- 7.5 ml/min/100 g in the vasoconstricted state for hydrogen gas clearance, xenon gas clearance, and radiolabeled microspheres, respectively. The H{sub 2} clearance technique resulted in tissue trauma, was complicated by frequent electrode displacement, and correlated poorly (r2 = 0.36, p greater than 0.05) with microsphere values. In contrast, xenon clearance measurement had no apparent effect on the pancreas and correlated well (r2 = 0.83, p less than 0.01) with microsphere data. We conclude that xenon clearance offers an attractive, validated alternative to radiolabeled microspheres for measuring pancreatic blood flow.

• OSTI ID: 5473327
• Journal Information: Pancreas; (USA), Journal Name: Pancreas; (USA) Vol. 4:2; ISSN PANCE; ISSN 0885-3177
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MICROSPHERES
NUCLEI
ORGANS
PANCREAS
RADIOISOTOPES
TRACER TECHNIQUES
VERTEBRATES
XENON 133
XENON ISOTOPES