Adrenergic vasoconstriction in peripheral nerves of the rabbit

Journal Article · Tue Jan 01 04:00:00 EST 1985 · Anesthesiology; (United States)

DOI:https://doi.org/10.1097/00000542-198501000-00002· OSTI ID:5663991

Selander, D; Mansson, L G; Karlsson, L; Svanvik, J

The blood flow in the sciatic nerve of the rabbit was estimated from the wash out of intraneurally injected /sup 133/Xe. To avoid diffusion of the tracer into the surrounding muscular tissue, the nerve was covered by a gas-tight plastic film. Using this technique, the basal blood flow in the sciatic nerve was estimated to 35 ml X min-1 X 100 g-1. It was found that intraarterial norepinephrine and electrical stimulation of the lumbar sympathetic chain strongly reduced the wash out of /sup 133/Xe, which only can be explained by a pronounced reduction of the blood flow in the nerve itself. The blood flow again increased within 4 min of stopping the infusion of norepinephrine or the sympathetic stimulation. The prolonged effect and higher neurotoxicity of local anesthetics containing adrenaline may be explained by an alpha receptor-mediated vasoconstriction of the microvessels of peripheral nerves.

• Research Organization: Univ. of Goeteborg, Sweden
• OSTI ID: 5663991
• Journal Information: Anesthesiology; (United States), Journal Name: Anesthesiology; (United States) Vol. 62:1; ISSN ANESA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
CARDIOTONICS
CARDIOVASCULAR AGENTS
DAYS LIVING RADIOISOTOPES
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRIC SHOCK
EVEN-ODD NUCLEI
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NERVES
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
NUCLEI
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
RABBITS
RADIOISOTOPES
RECEPTORS
SCIATIC NERVE
STEROID HORMONES
SYMPATHOMIMETICS
SYNTHETIC MATERIALS
TRACER TECHNIQUES
VASOCONSTRICTION
VERTEBRATES
XENON 133
XENON ISOTOPES